ALOX5 is implicated in chronic myeloid leukemia development in mouse leukemic stem cells, but its importance in human chronic myeloid leukemia is unknown.Functional ALOX5 was assessed using an LTB4 ELISA and ALOX5, and LTB4R1 mRNA expression was determined via a TaqMan gene expression assay.LTB4R1 and 5-LOX protein levels were assessed by cell surf
Cephalaria gigantea (Caprifoliaceae), a new alien species in the flora of Ukraine
Information about PASTEL MINT a locality of Cephalaria gigantea, a new for Ukraine alien species, is provided.It was found in the Podillya Botanical Garden, Vinnytsia city, in July 2016 during surveys of the spontaneous flora and vegetation of the garden and park landscapes of the Middle Pobuzhzhia area.The territory of the garden is currently rath
Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life: a longitudinal study
Abstract Background Anemia is common in HIV infection and independently associated with disease progression and mortality.The pathophysiology of HIV-related anemia is not well understood especially in infancy.Methods We conducted a longitudinal cohort study nested within the Zimbabwe Vitamin A for Mothers and Babies Project.We measured hemoglobin,
Head-to-Head Comparison of Novel Vaccine Technologies Comes with a Minefield of Challenges
Modern vaccine development is having a golden period, with a variety of novel subunit technologies being introduced into clinical development in recent years.This opens the opportunity to find the best platform to use for novel vaccine antigen candidates through head-to-head comparative studies.Seldom appreciated end table is, however, the fact tha